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Correct volume status in dehydrated or hypovolemic patients prior to initiating CELEBREXMonitor renal function in patients with renal or hepatic impairmentheart failuredehydrationor hypovolemia during use of CELEBREXsee DRUG INTERACTIONSAvoid the use of CELEBREX in patients with advanced renal disease unless the benefits are expected to outweigh the risk of worsening renal functionIf CELEBREX is used in patients with advanced renal diseasemonitor patients for signs of worsening renal function.

Low red blood cellsanemiapale skinfeeling light-headed or short of breathrapid heart ratetrouble concentratingor.

Advise females of reproductive potential who desire pregnancy that NSAIDsincluding CELEBREXmay be associated with a reversible delay in ovulationsee Use In Specific Populations

Celebrex may also cause stomach or intestinal bleedingwhich can be fatalThese conditions can occur without warning while you are using Celebrexespecially in older adultsYou should not take this medicine if you already have bleeding in your stomach or intestines.

The efficacy and safety of CELEBREX for JRA have not been studied beyond six monthsThe long-term cardiovascular toxicity in children exposed to CELEBREX has not been evaluated and it is unknown if the long-term risk may be similar to that seen in adults exposed to CELEBREX or other COX-2 selective and non-selective NSAIDssee BOXED WARNINGWARNINGS AND PRECAUTIONS

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signs of overdose on celebrex may include drowsiness, weakness, nausea, vomiting, and pain in the upper abdomen.